American Journal of Clinical Nutrition, Vol. 72, No. 5, 1088-1094, November 2000
Original Research Communication

Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory 1,2,3

Roland L Weinsier, Tim R Nagy, Gary R Hunter, Betty E Darnell, Donald D Hensrud and Heidi L Weiss
1 From the Departments of Nutrition Sciences and Human Studies, the General Clinical Research Center, and the Medical Statistics Section, University of Alabama at Birmingham, and the Mayo Clinic, Rochester, MN.
The T3 reverse T3 ratio decreases with acute and chronic calorie restriction and doses not return to normal levels after resuming a normal energy intake

Thyroid and Regaining Lost Weight after Dieting

• T3 falls during acute and chronic calorie   restriction
• Reverse T3 increases during acute and chronic
  calorie restriction, blocking thyroid effect and
  lowering metabolism
• Is this a factor why lost weight is usually regained?

Weinsier RL et al. Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory. Am J Clin Nutr 2000 Nov;72(5):1088-94