Endocrinological Assessment and Treatment of Obesity

Obesity has become a major health epidemic and has dramatically increased over the last decades. Studies show that now approximately one-third of the U.S. population is classified as obese and over two-thirds are significantly overweight. While the cause is multifactorial, studies are clear that almost all overweight individuals have metabolic and endocrinological dysfunction that is [...]

Reduced Metabolic Rate with Dieting

In 14 overweight women, 24-hour energy expenditure (EE) was measured in a whole-body indirect calorimeter: before weight reduction (100% diet), after 1 weeks on a 4.2-MJ diet, after 8 weeks on 4.2-MJ diet and after weight reduction on 100% diet. Mean body weight declined from 93.3 +/- 7.4 (mean +/- SD) to 83.4 +/- 7.7 kg; 24-hour EE decreased from 10.52 +/- 0.83 MJ on the 100% diet to 9.58 +/- 0.75 MJ on the 4.2- MJ diet.
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Thyroid and Regaining Lost Weight after Dieting

Roland L Weinsier, Tim R Nagy, Gary R Hunter, Betty E Darnell, Donald D Hensrud and Heidi L Weiss
1 From the Departments of Nutrition Sciences and Human Studies, the General Clinical Research Center, and the Medical Statistics Section, University of Alabama at Birmingham, and the Mayo Clinic, Rochester, MN.
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Reduced TSH with Weight Loss

Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-0920 BRIEF REPORT High Circulating Thyrotropin Levels in Obese Women Are Reduced after Body Weight Loss Induced by Caloric Restriction Petra Kok, Ferdinand Roelfsema, Janneke G. Langendonk, Marijke Frölich, Jacobus Burggraaf, A. Edo Meinders and Hanno Pijl Context: Previous clinical studies concerning the impact of body weight loss on single plasma TSH concentration [...]

Thyroid and Regaining Lost Weight after Dieting

American Journal of Clinical Nutrition, Vol. 72, No. 5, 1088-1094, November 2000 Original Research Communication Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory 1,2,3 Roland L Weinsier, Tim R Nagy, Gary R Hunter, Betty E Darnell, Donald D Hensrud and Heidi L Weiss 1 From the Departments [...]